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Rheumatology Diagnosis & Treatment Simplified
Comprehensive rheumatology video course by Medicosis Perfectionalis — joint anatomy, autoantibodies, rheumatoid arthritis, osteoarthritis, gout, lupus, scleroderma, vasculitis, bone disease, and neuromuscular disorders
109Tutorial Videos
11Modules
100%Free Access
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Foundations — Joints, History & Examination
6 videosIntroduction to Rheumatology — Let's Study Joints
Joint anatomy, classification, and approach to rheumatologic disease.
Rheumatology — Learning the Basics
Fundamental concepts — inflammatory vs non-inflammatory, monoarthritis vs polyarthritis.
How to Take a Good Patient History
Rheumatology-focused history — onset, pattern, morning stiffness, and systemic symptoms.
Rheumatology — Examining the Patient
Systematic MSK examination — inspection, palpation, range of motion, and special tests.
Arthropathy — Joint Pathology Classification
Inflammatory vs degenerative vs crystal vs infectious — systematic classification.
Concepts of Imaging Studies
X-ray, ultrasound, MRI, and CT — imaging selection in rheumatology.
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Rheumatology Labs — Autoantibodies & Markers
27 videosUnderstanding the Labs
Overview of rheumatology lab tests — RF, ANA, complement, ESR, CRP.
Mastering ANA — Antinuclear Antibodies
ANA testing — indications, patterns, and associated diseases.
ANA Patterns
Homogeneous, speckled, nucleolar, centromere — pattern significance.
ESR and CRP
Erythrocyte sedimentation rate vs C-reactive protein comparison.
C-Reactive Protein (CRP)
CRP as acute phase reactant — clinical significance and monitoring.
Acute Phase Reactants — ESR & CRP
Positive and negative acute phase reactants in inflammation.
ANCA — Anti-Neutrophilic Cytoplasmic Antibodies
ANCA testing — indirect immunofluorescence and ELISA.
c-ANCA vs p-ANCA
PR3 vs MPO — disease associations and clinical significance.
Rheumatoid Factor (RF)
RF testing — sensitivity, specificity, and conditions beyond RA.
Anti-CCP Antibodies
Anti-cyclic citrullinated peptide — high specificity for RA.
Anti-dsDNA Antibodies
Anti-double stranded DNA — SLE activity marker and lupus nephritis.
Anti-dsDNA — Mnemonic
Memory aid for anti-dsDNA associations.
Anti-Smith (Anti-Sm) Antibodies
Most specific antibody for SLE — nuclear antigen target.
Anti-dsDNA vs Anti-Smith
Comparing sensitivity vs specificity in lupus diagnosis.
Anti-U1-RNP Antibodies
Mixed connective tissue disease marker and overlap syndromes.
Anti-Ribosomal P Protein Antibodies
SLE neuropsychiatric manifestations and hepatitis association.
Anti-SSA (Anti-Ro) Antibodies
Sjögren's, neonatal lupus, and congenital heart block.
Anti-SSB (Anti-La) Antibodies
Sjögren's specific marker — usually with anti-SSA.
Antihistone Antibodies — Drug-Induced Lupus
Drug-induced lupus — hydralazine, procainamide, and isoniazid.
Anticentromere Antibodies
Limited scleroderma (CREST) marker.
Anti-RNA Polymerase III — Scleroderma
Diffuse scleroderma and renal crisis association.
Anti-Scl-70 (Anti-Topoisomerase I)
Diffuse scleroderma and pulmonary fibrosis marker.
Anti-Jo-1 (Anti-Synthetase) Antibodies
Antisynthetase syndrome — ILD, myositis, mechanic's hands.
Hypocomplementemia — Low Complement in Lupus
C3/C4 consumption — active SLE and immune complex disease.
HLA — Major Histocompatibility Complex
MHC class I and II — antigen presentation and disease associations.
HLA-B27
Spondyloarthropathies — AS, reactive arthritis, psoriatic arthritis, and IBD.
HLA-DR2, DR3, DR4 (MHC Class II)
HLA class II disease associations — SLE, RA, T1DM, and celiac.
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Joint Fluid Analysis
3 videosJoint Fluid Analysis — Physiology
Normal synovial fluid — composition, viscosity, and function.
Joint Fluid Analysis — Pathology
Arthrocentesis interpretation — WBC count, crystals, culture, and classification.
Joint Effusions
Noninflammatory vs inflammatory vs septic — differential diagnosis.
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Osteoarthritis
7 videosOsteoarthritis — Introduction
OA overview — degenerative joint disease and clinical significance.
OA — Definition, Causes & Epidemiology
Primary vs secondary OA — risk factors and affected joints.
OA — Pathophysiology
Cartilage degradation, subchondral sclerosis, and osteophyte formation.
OA — Signs and Symptoms
Heberden's/Bouchard's nodes, crepitus, and pain pattern.
OA — Diagnosis
Clinical criteria, X-ray findings, and lab exclusion.
OA — Treatment
NSAIDs, physical therapy, intra-articular injections, and joint replacement.
OA — Quick Review
Complete OA summary for rapid board review.
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Rheumatoid Arthritis
23 videosRA — Introduction
Autoimmune inflammatory arthritis — overview and clinical importance.
RA — Definition, Etiology & Epidemiology
Genetic and environmental risk factors, female predominance.
RA — Pathophysiology
Pannus formation, synovial inflammation, and joint destruction.
RA — Articular Manifestations
Symmetric polyarthritis, swan neck, boutonniere, ulnar deviation.
RA — Atlantoaxial Instability
Cervical spine involvement — subluxation risk and surgical indications.
RA — Extra-Articular Manifestations
Rheumatoid nodules, pulmonary, cardiac, and ocular involvement.
RA — Anemia in Rheumatoid
Anemia of chronic disease, iron deficiency, and Felty syndrome.
RA — Diagnosis
ACR/EULAR criteria, RF, anti-CCP, imaging, and scoring.
RA — Prognosis
Prognostic factors, disease activity scores, and outcomes.
Caplan Syndrome
RA + coal worker's pneumoconiosis — lung nodules.
Felty Syndrome
RA + splenomegaly + neutropenia triad.
Felty Syndrome — Mnemonic
Memory aid for the Felty syndrome triad.
RA — Management Introduction
Treatment principles — treat-to-target and step-up approach.
RA — DMARDs Overview
Conventional DMARDs — methotrexate, leflunomide, sulfasalazine.
RA — Hydroxychloroquine & Synthetic DMARDs
HCQ mechanism, retinal toxicity, and combination therapy.
Sulfasalazine (SSZ) — Mnemonic
Memory aid for sulfasalazine mechanism and side effects.
RA — Small-Molecule DMARDs
JAK inhibitors — tofacitinib, baricitinib mechanism and use.
RA — TNF Inhibitor DMARDs
Infliximab, adalimumab, etanercept — mechanisms and monitoring.
RA — Non-TNF Biological DMARDs
Rituximab, abatacept, tocilizumab — mechanisms and indications.
RA — Small Molecules (Advanced)
Targeted synthetic DMARDs and emerging therapies.
RA — Mnemonic
Comprehensive memory aid for RA features.
RA — Quick Review
Complete RA summary for rapid review.
RA vs Osteoarthritis
Side-by-side comparison — inflammatory vs degenerative features.
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Crystal Arthropathies — Gout & Pseudogout
12 videosGout — Overview
Monosodium urate crystals — pathophysiology, risk factors, and clinical features.
Gout — Diagnosis
Needle-shaped negatively birefringent crystals, imaging, and uric acid levels.
Purine Metabolism & Uric Acid
De novo synthesis, salvage pathway, and degradation to uric acid.
Gout — Management
Acute flare treatment and urate-lowering therapy goals.
Gout — Xanthine Oxidase Inhibitors
Allopurinol and febuxostat — mechanisms, dosing, and monitoring.
Pegloticase — Uricase Therapy
Recombinant uricase for refractory gout — mechanism and infusion reactions.
Gout — Mnemonic
Memory aid for gout features and treatment.
Pseudogout — CPPD Disease
Calcium pyrophosphate crystals — rhomboid, positively birefringent.
Pseudogout vs Osteoarthritis
Differentiating CPPD from degenerative disease.
Gout vs Pseudogout
MSU vs CPPD — crystal comparison, joints, and treatment differences.
Hydroxyapatite Arthropathy
Milwaukee shoulder — destructive arthropathy and pseudo-pseudogout.
Gout vs Pseudogout vs Hydroxyapatite
Three-way crystal arthropathy comparison.
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Sjögren Syndrome
4 videosSjögren vs Sicca Syndrome
Primary vs secondary Sjögren and sicca syndrome differentiation.
Sjögren Syndrome — Comprehensive
Dry eyes, dry mouth, arthritis — pathophysiology and systemic features.
Sjögren — Diagnosis & Management
Schirmer test, lip biopsy, and treatment of sicca symptoms.
Sjögren — Mnemonic
Memory aid for Sjögren features and associations.
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Scleroderma (Systemic Sclerosis)
7 videosScleroderma — Signs & Symptoms
Skin thickening, Raynaud's, GI dysmotility, and organ involvement.
Scleroderma Subtypes (5 Types)
Limited vs diffuse, overlap, sine scleroderma, and environmentally induced.
Scleroderma — Pathogenesis & Clinical
Vasculopathy, fibrosis, and autoimmunity — detailed pathophysiology.
Limited (CREST) vs Diffuse Scleroderma
CREST syndrome vs diffuse — antibodies, organ involvement, and prognosis.
Scleroderma — Diagnosis & Management
Modified Rodnan skin score, autoantibodies, and treatment approach.
Raynaud Phenomenon
Primary vs secondary Raynaud's — vasospasm, ischemia, and calcium channel blockers.
Mixed Connective Tissue Disease — Mnemonic
MCTD overlap features — anti-U1-RNP and treatment.
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Vasculitis & Seronegative Spondyloarthropathies
3 videosGiant Cell Arteritis (Temporal Arteritis)
Large vessel vasculitis — headache, jaw claudication, and ESR >50.
Granulomatosis with Polyangiitis (Wegener's)
c-ANCA vasculitis — ENT, lung, kidney involvement and cyclophosphamide.
Ankylosing Spondylitis
HLA-B27 spondyloarthropathy — bamboo spine, sacroiliitis, and biologics.
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Bone Disease
7 videosPaget Disease of Bone — Mnemonic
Osteitis deformans — elevated ALP, hearing loss, and bisphosphonate therapy.
Osteitis Fibrosa Cystica — CKD Complication
Renal osteodystrophy — secondary hyperparathyroidism and bone resorption.
Osteogenesis Imperfecta — Brittle Bone Disease
Type I collagen defect — fractures, blue sclerae, and hearing loss.
Osteogenesis Imperfecta — Mnemonic
Memory aid for OI types and features.
Osteomyelitis
Bone infection — S. aureus, hematogenous spread, and treatment.
Bone Tumors
Osteosarcoma, Ewing sarcoma, giant cell tumor, and chondrosarcoma.
Bone Structure & Remodeling
Osteoblasts, osteoclasts, bone matrix, and remodeling cycle.
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Neuromuscular & Systemic
10 videosMyasthenia Gravis
Anti-AChR antibodies — fatigable weakness, edrophonium test, and thymectomy.
Lambert-Eaton Myasthenic Syndrome
Anti-VGCC antibodies — proximal weakness, autonomic dysfunction, and small cell lung cancer.
Myasthenia Gravis vs Lambert-Eaton
Key differences — pattern of weakness, reflexes, antibodies, and treatment.
POTS — Postural Orthostatic Tachycardia
Orthostatic intolerance — tilt table testing and management.
Paraneoplastic Syndromes
Cancer-associated autoimmunity — ectopic hormones and neurological syndromes.
Pain — Gate Theory
Pain physiology — gate control, opioid mechanisms, and pain modulation.
Edema — Pitting vs Non-Pitting
Exudate vs transudate, hydrostatic vs oncotic pressure.
Histamine & Anaphylaxis
H1-H4 receptors, mast cell degranulation, and allergic pathways.
Antibodies (Immunoglobulins)
IgG, IgM, IgA, IgE, IgD — structure, function, and clinical significance.
Immunosuppressive Drugs
Calcineurin inhibitors, antimetabolites, and biologics for autoimmune disease.