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Hematology Diagnosis & Treatment Simplified
Comprehensive hematology video course — blood cell formation, anemias, polycythemia, hemolytic disorders, leukemia, lymphoma, myeloproliferative neoplasms, coagulation, bleeding disorders, thrombophilia, and transfusion medicine from Ninja Nerd, JJ Medicine, Alila Medical, and Dr. Waqas
101Tutorial Videos
12Modules
100%Free Access
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Hematopoiesis & Blood Basics
13 videosHematopoiesis — Formation of Blood Cells
Stem cell differentiation — myeloid and lymphoid lineages, growth factors, and bone marrow niches.
Hematocrit | Ninja Nerd
Hematocrit definition, normal ranges, and clinical significance.
Erythropoiesis Part 1: RBC Formation | Ninja Nerd
Red blood cell development — proerythroblast to reticulocyte, EPO regulation.
Erythropoiesis Part 2: Lifespan & Destruction | Ninja Nerd
RBC lifespan, splenic sequestration, and extravascular hemolysis.
How RBCs Carry Oxygen and CO2
Hemoglobin oxygen binding, Bohr effect, and CO2 transport mechanisms.
Red Blood Cell Life Cycle & Disorders
RBC production, destruction, and overview of red cell disorders.
Leukopoiesis: WBC Formation | Ninja Nerd
Granulocyte, monocyte, and lymphocyte development pathways.
Heme Synthesis Pathway
ALA synthase to protoporphyrin IX — rate-limiting steps and porphyria connections.
Heme Catabolism & Degradation
Heme to biliverdin to bilirubin — conjugation, excretion, and jaundice.
Blood Types & Transfusion Rules
ABO and Rh systems — universal donor/recipient and transfusion compatibility.
Blood Typing | Ninja Nerd
ABO antigens, antibodies, crossmatching, and Coombs testing.
Hemolytic Disease of the Newborn
Rh incompatibility — pathophysiology, hydrops fetalis, and RhoGAM prevention.
Blood Transfusions | Ninja Nerd
Indications, components, reactions, and transfusion-associated complications.
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Approach to Anemia
5 videosCBC | Approach to Anemia | Ninja Nerd
Systematic CBC interpretation — MCV-based classification and reticulocyte index.
Types of Anemias | Ninja Nerd
Overview of anemia classification — production defect vs destruction vs blood loss.
Anemia: Microcytic vs Normocytic vs Macrocytic
MCV-based differential diagnosis — iron studies, B12/folate, and reticulocyte count.
What Is Anemia & How to Find the Cause
Simplified diagnostic approach for anemia evaluation.
Hematology Lectures Part 1: Anemias Overview
Comprehensive anemia introduction — classification, pathophysiology, and clinical approach.
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Microcytic Anemias
12 videosMicrocytic Anemia | Ninja Nerd
Iron deficiency, thalassemia, ACD, sideroblastic, and lead poisoning — differential diagnosis.
Microcytic Anemia & Causes
Iron deficiency, thalassemia, anemia of chronic disease, and lead poisoning compared.
Iron-Deficiency Anemia — Overview
Pathophysiology, iron studies, ferritin, TIBC, and oral vs IV iron replacement.
Iron-Deficiency Anemia Signs & Symptoms
Fatigue, koilonychia, pica, glossitis, and angular cheilitis.
Weird Symptoms of Iron Deficiency
Nails, tongue, skin, hair — unusual manifestations of iron deficiency.
Causes of Iron-Deficiency Anemia
Dietary, blood loss, malabsorption, and increased utilization causes.
Hematology Lectures Part 2: IDA
In-depth iron deficiency anemia lecture — labs, diagnosis, and treatment.
Anemia of Chronic Disease
Hepcidin-mediated iron sequestration — pathophysiology and EPO therapy.
Lead Poisoning
Lead sources, basophilic stippling, ringed sideroblasts, and chelation.
Thalassemia: Alpha & Beta
Genetics, pathophysiology, target cells, and transfusion/chelation management.
Hematology Lectures Part 3: Thalassemia
Beta-thalassemia major/minor/intermedia — clinical features and management.
Hematology Lectures Part 4: Alpha Thalassemia & Sideroblastic
Alpha thalassemia types and sideroblastic anemia — ringed sideroblasts.
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Macrocytic & Megaloblastic Anemias
5 videosMacrocytic Anemia | Ninja Nerd
Megaloblastic vs non-megaloblastic — B12, folate, liver disease, and hypothyroidism.
Macrocytic Anemia | Megaloblastic vs Non-Megaloblastic
Hypersegmented neutrophils, elevated homocysteine/MMA, and diagnostic approach.
Pernicious Anemia
Anti-intrinsic factor antibodies — B12 deficiency, neurological damage, and Schilling test.
Hematology Lectures Part 5: Megaloblastic Anemia
B12 and folate deficiency — biochemistry, clinical features, and treatment.
Hematology Lectures Part 6: Megaloblastic Anemia (Continued)
Advanced megaloblastic anemia — diagnostic workup and management.
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Normocytic & Hemolytic Anemias
13 videosNormocytic Anemia | Ninja Nerd
Hemolysis, aplastic anemia, ACD, and acute blood loss — diagnostic approach.
Hemolytic Anemia Overview
Intravascular vs extravascular — LDH, haptoglobin, reticulocytes, and Coombs test.
Hereditary Spherocytosis
Spectrin/ankyrin defects — osmotic fragility, splenomegaly, and splenectomy.
G6PD Deficiency
Oxidative stress — Heinz bodies, bite cells, fava beans, and drug triggers.
Sickle Cell Disease
HbS polymerization — vaso-occlusive crisis, acute chest, and hydroxyurea.
Sickle Cell Disease — Detailed
Pathophysiology, clinical complications, and comprehensive management.
Pyruvate Kinase Deficiency
Glycolytic enzyme defect — chronic hemolysis, echinocytes, and splenectomy.
Autoimmune Hemolytic Anemia
Warm IgG vs cold IgM — Coombs test, steroids, and rituximab.
Paroxysmal Nocturnal Hemoglobinuria
GPI anchor defect — complement-mediated lysis, flow cytometry, and eculizumab.
Methemoglobinemia
Oxidized hemoglobin — chocolate-brown blood, pulse ox gap, and methylene blue.
Hematology Lectures Part 7: Hemolytic Anemia & Spherocytosis
Hereditary spherocytosis — membrane defects, diagnosis, and treatment.
Hematology Lectures Part 8: Sickle Cell
SCD pathophysiology, crises, and management lecture.
Hematology Lectures Part 9: G6PD, PNH & Autoimmune
G6PD, PNH, and autoimmune hemolytic anemia comparison.
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Polycythemia & Erythrocytosis
7 videosPolycythemias | Ninja Nerd
Primary vs secondary — relative vs absolute polycythemia classification.
CBC | Approach to Polycythemia | Ninja Nerd
Systematic evaluation — EPO levels, JAK2, and oxygen saturation.
Polycythemia Vera
JAK2 V617F mutation — erythrocytosis, pruritus, thrombosis, and phlebotomy.
High Red Blood Cells (Erythrocytosis)
Causes of elevated RBC count — altitude, hypoxia, EPO-secreting tumors.
Polycythemia Signs & Symptoms
Plethora, headache, pruritus, and thrombotic complications.
What Is Polycythemia?
Hemoglobin, hematocrit thresholds, and classification overview.
Altitude Sickness
High-altitude erythrocytosis, AMS, HACE, HAPE, and acclimatization.
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Leukemia
8 videosLeukemia: Pathophysiology & Types
ALL, AML, CLL, CML — pathophysiology, symptoms, diagnosis, and treatment overview.
Acute Leukemia | Ninja Nerd
ALL vs AML — blast morphology, flow cytometry, cytogenetics, and chemotherapy.
Chronic Leukemia | Ninja Nerd
CLL vs CML — smudge cells, Philadelphia chromosome, and TKI therapy.
CML: Pathogenesis, Symptoms & Treatment
BCR-ABL fusion — phases, imatinib, and monitoring response.
CLL: Symptoms, Diagnosis & Treatment
Smudge cells, Rai/Binet staging, and treatment indications.
Hematology Lectures Part 10: Acute Leukemias
ALL and AML classification, presentation, and initial workup.
Hematology Lectures Part 11: Acute Leukemia (Continued)
Treatment protocols and prognostic factors in acute leukemia.
Hematology Lectures Part 12: Chronic Leukemia
CML and CLL — diagnosis, staging, and treatment.
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Lymphoma, Myeloma & MDS
9 videosLymphoma: Hodgkin & Non-Hodgkin
Reed-Sternberg cells, Ann Arbor staging, NHL subtypes, and treatment approaches.
Lymphoma | Ninja Nerd
HL vs NHL — DLBCL, follicular, Burkitt, mantle cell classification and management.
Myeloproliferative Neoplasms | Ninja Nerd
PV, ET, PMF, CML — JAK2/CALR mutations, diagnosis, and treatment.
Plasma Cell Disorders | Ninja Nerd
Multiple myeloma, MGUS, Waldenström's — M-protein, CRAB criteria, and therapy.
Amyloidosis | Ninja Nerd
AL vs AA amyloidosis — Congo red, organ involvement, and treatment.
MDS | Ninja Nerd
Myelodysplastic syndromes — cytopenias, dysplasia, and transformation to AML.
Hematology Lectures Part 13: Lymphoma
Hodgkin and non-Hodgkin lymphoma classification and treatment.
Hematology Lectures Part 14: Myeloproliferative Diseases
PV, ET, myelofibrosis — clinical features and management.
Hematology Lectures Part 15: Multiple Myeloma
Bone pain, renal failure, anemia, hypercalcemia — CRAB and treatment.
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Hemostasis & Coagulation
7 videosCoagulation Cascade | Ninja Nerd
Intrinsic, extrinsic, and common pathways — factors, PT, aPTT, and INR.
Hemostasis: Control of Bleeding & Thrombosis
Primary hemostasis (platelet plug) and secondary hemostasis (fibrin clot) overview.
Secondary Hemostasis — Coagulation Cascade
Detailed cascade — tissue factor, thrombin generation, and fibrin polymerization.
Coagulopathy | Ninja Nerd
PT/aPTT-based approach — liver disease, DIC, vitamin K deficiency, and factor inhibitors.
Hematology Lectures Part 18: Bleeding Disorders
Platelet vs coagulation disorders — clinical and laboratory differentiation.
Hematology Lectures Part 19: Bleeding Disorders (Continued)
Von Willebrand disease, platelet function disorders, and workup.
Hematology Lectures Part 20: Coagulation Disorders & Hemophilia
Hemophilia A/B, DIC, and anticoagulant-related bleeding.
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Bleeding Disorders
9 videosThrombocytopenia: Signs, Symptoms & Causes
Low platelet approach — ITP, TTP, HUS, DIC, and drug-induced causes.
Low Platelets Signs & Symptoms
Petechiae, purpura, mucosal bleeding, and when to transfuse.
Platelet Disorders | Ninja Nerd
Quantitative and qualitative platelet disorders — ITP, TTP, HIT, Bernard-Soulier.
Heparin-Induced Thrombocytopenia (HIT)
Type 1 vs Type 2 — 4T score, PF4 antibodies, and argatroban therapy.
Hemophilia A vs Hemophilia B
Factor VIII vs IX deficiency — genetics, bleeding pattern, and replacement therapy.
Von Willebrand Disease
Types 1-3 — ristocetin cofactor, DDAVP, and VWF concentrate therapy.
Hereditary Hemorrhagic Telangiectasia
Osler-Weber-Rendu — epistaxis, AVMs, and genetic vascular disorder.
Porphyria: PCT vs AIP
Porphyria cutanea tarda vs acute intermittent — enzyme defects and presentations.
Acute Intermittent Porphyria
AIP triggers, neurovisceral attacks, urine porphobilinogen, and hemin therapy.
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Thrombophilia & Thrombocytosis
8 videosHypercoagulable States | Ninja Nerd
Inherited and acquired thrombophilia — Factor V Leiden, protein C/S, antiphospholipid.
Excessive Clotting (Hypercoagulation)
Virchow's triad — causes of venous and arterial thrombosis.
Factor V Leiden
Activated protein C resistance — DVT risk, screening, and anticoagulation.
What Causes High Platelets (Thrombocytosis)
Reactive vs clonal — infection, iron deficiency, and myeloproliferative causes.
High Platelets Signs & Symptoms
Thrombosis, bleeding, and vasomotor symptoms in thrombocytosis.
Causes of High Platelets | Rapid Review
Reactive vs autonomous — diagnostic approach.
Thrombocytosis: Diagnosis & Treatment
Workup algorithm, JAK2 testing, and treatment indications.
What High Platelets Mean & How Platelets Are Created
Thrombopoiesis and clinical significance of elevated platelet count.
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Hematology Pharmacology
5 videosAnticoagulants
Heparin, warfarin, DOACs — mechanisms, monitoring, and reversal agents.
Thrombolytics (Fibrinolytics)
tPA, alteplase, tenecteplase — mechanisms, indications, and bleeding risk.
Antiplatelets, Anticoagulants & Thrombolytics | Ninja Nerd
Comprehensive antihrombotic pharmacology — aspirin, clopidogrel, heparin, warfarin, DOACs.
Sepsis & Septic Shock — DIC Connection
Sepsis-induced coagulopathy — DIC pathophysiology and management.
A1C Test for Diabetes — Hemoglobin Connection
Glycated hemoglobin — RBC lifespan, HbA1c interpretation, and limitations.